Essay On Pluripotent Cells - 1143 Words

). The use of pluripotent cells, allow researchers to conduct drug testing in a wide range of cell types. Thus, improving outcomes for patients with many neurological diseases. The loss of neurons and glial cells cause neurological disorders, such as Parkinson’s disease and multiple sclerosis. Current major therapies focus on oral medications, in the case of Parkinson’s disease, L-dopa, and dopamine receptor agonists, in addition to deep-brain stimulation in the subthalamic nucleus. Furthermore, the use of a VNS device to prevent seizures is also commonly used for those with epilepsy. These treatments are effective for some symptoms, but are linked to side effects and do not halt the progression of the disease. â€Å"To be clinically†¦show more content†¦Consequently, researchers have found that the use of undifferentiated cells to suppress inflammation as well as remyelinate axons is a viable alternative to or in conjunction with current treatment of those with Alzheimer’s disease. For patients and their families, the research behind embryonic stem cells offers them the hope of a cure for chronic and debilitating conditions, such as Alzheimer’s disease, Parkinson’s disease, Epilepsy, ALS, Huntington’s Disease, MS and Cerebral Palsy. For scientists, however, it epitomizes the innovative path of discovery. Discovering the causes and subsequent cures for EMBRYONIC STEM CELLS AND NEUROLOGICAL DISEASE 7 human conditions. According to Lindvill et al, Stem cell therapies to restore and preserve function in the brain and spinal cord can be developed (2006). Bioethics of stem cell-based therapy Researchers must overcome many hurdles, including moral and ethical issues before the clinical application of cell therapy in neurological disease patients, are implemented. Therefore, continued research is needed in stem cell research in both basic and preclinical settings. This can be accomplished through education as well as positive research outcomes. Supporting the hope for the continued development of stem cell-based therapies for neurodegenerative diseases. Embryonic stem cells have been derived from a variety ofShow MoreRelatedPluripotent Stem Cell Essay1608 Words   |  7 Pageson â€Å"Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors†  ¬Stem cells are yet undifferentiated cells, with the potential capability to further divide indefinitely, and the ability to give rise to more specialized cell types. Embryonic stem(ES) cells are of especially great importance due to their pluripotency and hence ability to differentiate to cells of all three germ layers. Due to the great replicative powers of these cells, they may be usedRead MoreEssay On Pluripotent Cells For Toxicology742 Words   |  3 Pages1.3.1 Pluripotent cells for toxicology (relevant cells relevant species) In 1981, ESCs were firstly developed from isolation of mouse blastocytes (PMID: 7242681), then human ESCs were derived in 1998 (PMID: 9804556). Subsequently, the derivation of human ESC line did not only raise critical ethical, religious, and political controversies, but also had scientific limitation. To circumvent these concerns, suggested the derivation of iPSCs which seemed to be a promising and great alternative thoughRead MoreInduced Pluripotent Stem Cells Essays1185 Words   |  5 PagesDescribe:- (i) how induced pluripotent stem cells (iPSCs) are isolated (ii) how iPSCs can be used to study human development (iii) how iPSCs can be used to model human disease and to develop therapies for degenerative disease i) iPSCs are adult stem cells that have been genetically reprogrammed to behave like the pluripotent stem cells found in embryos, i.e. can differentiate into any cell type in the human body. This was first completed successfully in mice in 2006 by Shinya Yamanaka and hisRead MoreInduced Pluripotent Stem Cells Essay1759 Words   |  8 Pages Induced Pluripotent Stem Cells: Methods of Production, Characterization and Applications to Medicine Student’s Name University Induced Pluripotent Stem Cells: Methods of Production, Characterization and Applications to Medicine Introduction By definition, induced pluripotent stem cells (iPSCs) are somatic cells with preprogrammed features (Kamath et al. 2017). In essence, they are often modified to mimic embryonic stem cells through the expression of ectopic factors linked to geneRead More Stem Cells: What How and Why? Essay1130 Words   |  5 Pages Stem Cells: What, How and Why? Stem cells are infinitely valuable when considering their potential applications in the medical profession. While current legislative restrictions have halted the development of new ?stem cell lines? to any agency or company that receives any form of governmental grants, there is no question that the medical profession is standing at the brink of a new era of technological advancements in healthcare and research. Stem cells are valuable due to the fact that theyRead MoreProgress in the Reasearch on Induced Pluripotent Stem Cells 528 Words   |  3 Pagesin stem cell research. They reprogrammed mouse skin fibroblasts by introduction of four transcription factors, Oct3/4, Sox2, Klf4 and c-Myc and generated cells almost indistinguishable from ES cells. They named these cells induced pluripotent stem cells (iPSCs) (Takahashi K., et al., 2006). An year later, James A. Thomson et al. replaced Oct4 and oncogenic c-Myc with Lin28 and Nanog decreasing the risk of cancer formation (Yu J., et al., 2007). We need to take into consideration that cell types areRead MoreEssay On 20 Years Of Advancement In Healthcare Science1109 Words   |  5 Pagestwenty years there have been numerous important advances throughout healthcare science. These have allowed for improved diagnoses and more effective treatments lowering the prevalence of diseases. The first significant advancement discussed in this essay is The Human Genome Project (HGP), an international collaborative research program whose goal was to sequence and map all of the genes (known as the genome) contained within humans. This project has revolutionised the biomedical field and has alreadyRead MoreEssay about Alternatives to Human-embryo Stem-cell Research1145 Words   |  5 PagesHuman-embryo Stem-cell Research      Ã‚   This essay counters the media and many scientists claims that there are no viable alternatives to human-embryo stem-cell research (ESCR).    The media restate the claim (made repeatedly in NIH documents) that adult stem cells do not have the same potential as embryonic stem cells, which in theory can form any tissue. But studies done with adult stem cells (studies which mirror the ones done with embryonic stem cells) show that adult stem cells do have theRead MoreEssay about Advances in Parkinson’s Disease1345 Words   |  6 Pagessymptoms of Parkinson’s disease have been recorded from years dating all the way back to about 1000 B.C., but the first actual medical diagnosis of the disease was done by James Parkinson in 1817 (Goetz). He published his findings in a book entitled An Essay on the Shaking Palsy. Shaking palsy was the name of the Parkinson’s disease before another scientist named the disease after Parkinson because of his findings. Later a man named Jean-Martin Charcot made an important finding in which he was able toRead MoreThe Function Of The Hair Follicle Stem Cells1239 Words   |  5 Pagesintrinsic or extrinsic expression of specific proteins. Hair follicle stem cells are responsible for not only its self-renewal but also in the production of rapidly multiplying cells. The stem cells of the hair follicle are for temporary increase in cells, and are created by the differentiation of hair follicle stem cells. The focus of this essay will be to analyze a specific protein within the hair follicle stem cell BMP, bone morphogenetic proteins. Through intrinsic expression, Bone morphogenetic